Cenforce 200 mg may be administered with or without food, but for optimal effects, it should be administered on an empty stomach. If taken with a large or high-fat meal, the bioavailability of sildenafil (the active component) would be delayed, decreasing the efficacy of the drug and delaying its action. Taking it on an empty stomach generally makes the medication take effect sooner, commonly within 30 to 60 minutes. ​